Senator Joseph R. Biden Jr. of Delaware accepted the Democratic vice-presidential nomination on Wednesday night with an ode to his middle-class upbringing and a blistering attack on Senator John McCain.

On tax policy and the war in Iraq, on health care and terrorism, on the minimum wage and on Russia, Mr. Biden said, the contrast was clear between Mr. McCain and the Democratic presidential nominee, Senator Barack Obama.

“Again and again,” he said, “on the most important national security issues of our time, John McCain was wrong, and Barack Obama was proven right.”

He said Mr. McCain had supported President Bush’s policies that Mr. Biden said had driven the American economy into a ditch and backed Mr. Bush on a war that is costing American taxpayers $12 billion a month.

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